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An eye to clinical research, the questionable hornet's nest also includes epidemiological aspects; identification of patients; the definition of the most competent primary intention point; the wherewithal to delineate ran- domized trials; new statistical approaches such as crossover studies, Bayesian statistics, or unvaried using the patient as her own guide; the need towards an intergroup setting with associ- ated administrative costs and requirements; and matrix but not least the situation of rigorous partnerships with pharma- ceutical companies in this context [46]. Am J Respir Cubicle Mol Biol 24:282В­294 Yamazaki Y, Tsuruga M, Zhou D, Fujita Y, Shang X, Dang Y, Kawasaki K, Oka S (2000) Cytoskeletal disruption accelerates caspase-3 activation and alters the intracellular membrane reorganization in DNA damage-induced apoptosis. 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